Stress-induced formation of cell wall-deficient cells in filamentous actinomycetes

Bacteria can be forced to grow without cell wall if cell wall synthesis is inhibited. Here Ramijan et al. show that, in filamentous actinomycetes, hyperosmotic stress induces formation of wall-deficient cells that can switch to normal mycelial growth, or mutate and proliferate indefinitely as wall-l...

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Bibliographic Details
Main Authors: Karina Ramijan, Eveline Ultee, Joost Willemse, Zheren Zhang, Joeri A. J. Wondergem, Anne van der Meij, Doris Heinrich, Ariane Briegel, Gilles P. van Wezel, Dennis Claessen
Format: Article
Language:English
Published: Nature Publishing Group 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07560-9