Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway

Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway

Dysfunction of the N-methyl-d-aspartate (NMDA) receptor has been implicated in the pathogenesis of schizophrenia. Although agonists for the glycine-binding sites of NMDA receptors have potential as new medication for schizophrenia, their modulation of antipsychotic-induced extrapyramidal side effect...

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Bibliographic Details
Main Authors: Saki Shimizu, Shunsaku Sogabe, Ryoto Yanagisako, Akiyoshi Inada, Megumi Yamanaka, Higor A. Iha, Yukihiro Ohno
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:International Journal of Molecular Sciences
Subjects:
antipsychotics
">d-cycloserine
extrapyramidal side effects
glycine-binding site agonists of NMDA receptors
nigrostriatal dopaminergic system
schizophrenia
Online Access:https://www.mdpi.com/1422-0067/18/7/1416

Internet

https://www.mdpi.com/1422-0067/18/7/1416

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