miR-142 downregulation alleviates rat PTSD-like behaviors, reduces the level of inflammatory cytokine expression and apoptosis in hippocampus, and upregulates the expression of fragile X mental retardation protein

miR-142 downregulation alleviates rat PTSD-like behaviors, reduces the level of inflammatory cytokine expression and apoptosis in hippocampus, and upregulates the expression of fragile X mental retardation protein

Abstract Background FMRP is a selective mRNA-binding protein that regulates protein synthesis at synapses, and its loss may lead to the impairment of trace fear memory. Previously, we found that FMRP levels in the hippocampus of rats with post-traumatic stress disorder (PTSD) were decreased. However...

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Bibliographic Details
Main Authors: Peng-Yin Nie, Lei Tong, Ming-Da Li, Chang-Hai Fu, Jun-Bo Peng, Li-Li Ji
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
Post-traumatic stress disorder
miR-142
NF-κB
FMRP
Inflammation
Online Access:https://doi.org/10.1186/s12974-020-02064-0

Internet

https://doi.org/10.1186/s12974-020-02064-0

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