"Beneficial effects of vitamin C and vitamin E on blood pressure in Hyperandrogenic women "

• Main Authors: Sotoudeh G, Siassi F, Mirdamadi SR, Mohammad K, Golestan B, Chamari M
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2002-09-01
• Series: Acta Medica Iranica
• Subjects: Androgen excess
• Online Access: https://acta.tums.ac.ir/index.php/acta/article/view/2606

Hyperandrogenism affects 2-6% of all women. Hypertension is one of disturbances which is related to androgen excess. Higher intakes of vitamin C and vitamin E have been associated with lower blood pressure. Tho investigate the effect of these vitamin supplementation on blood pressure in hyperandrogenic women, a randomized, double-blind, placebo-controlled study was designed on 56 women 18-54 years old. Women were randomly allocated to one of four treatment groups: spironolactone plus vitamain C and viamin E (SCE), spironolactone plus vitamins placebo (SP), vitamin C plus vitamin E (CE), vitamins placebo (P). The treatment consisted of oral administration of 100 mg spironolactone, 1000 mg vitamin C and 900 mg vitamin E (alpha-tocopherol acetate) daily for about 3 months. Results indicated that compared to pretreatment, vitamins supplementation significantly lowered systolic (119.1±12.6 vs. 112.6±15.4 mmHg) and mean blood pressure (97.4±11.5 vs. 92. ±12.1 mmHg) SCE group (P