Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca<sup>2+</sup> Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation
Substitution of Ala for Glu residue in position 173 of γ-tropomyosin (Tpm3.12) is associated with muscle weakness. Here we observe that this mutation increases myofilament Ca<sup>2+</sup>-sensitivity and inhibits in vitro actin-activated ATPase activity of myosin subfragment-1 at high Ca...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/12/4421 |