Research advances in erythrocyte regeneration sources and methods in vitro

Research advances in erythrocyte regeneration sources and methods in vitro

Erythrocytes (red blood cells, RBCs) facilitate gas exchange in the lungs and transport oxygen to the tissues. The human body must maintain erythrocyte regeneration to support metabolically active cells and tissues. In many hematological diseases, erythrocyte regeneration is impaired. Researchers ha...

Full description

Bibliographic Details
Main Authors: Shuming Sun, Yuanliang Peng, Jing Liu
Format: Article
Language:English
Published: SpringerOpen 2018-12-01
Series:Cell Regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2045976918300117
id doaj-bf94d88267ef4c0d81b06bf69a30e31f
record_format Article
spelling doaj-bf94d88267ef4c0d81b06bf69a30e31f2020-11-25T03:32:56ZengSpringerOpenCell Regeneration2045-97692018-12-01724549Research advances in erythrocyte regeneration sources and methods in vitroShuming Sun0Yuanliang Peng1Jing Liu2Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China; Erythropoiesis Research Center, Central South University, Changsha 410078, ChinaMolecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China; Erythropoiesis Research Center, Central South University, Changsha 410078, ChinaMolecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China; Erythropoiesis Research Center, Central South University, Changsha 410078, China; Corresponding author. Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.Erythrocytes (red blood cells, RBCs) facilitate gas exchange in the lungs and transport oxygen to the tissues. The human body must maintain erythrocyte regeneration to support metabolically active cells and tissues. In many hematological diseases, erythrocyte regeneration is impaired. Researchers have studied erythrocyte regeneration for many years both in vivo and in vitro. In this review, we summarize the sources and main culture methods for generating mature and functional red blood cells in vitro. Hematopoietic stem cells (HSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are classic sources for erythrocyte regeneration. In addition, alternative sources such as immortalized adult human erythroid cell lines and transformed fibroblasts have also been generated and have produced functional red blood cells. The culture systems for erythrocytes differ among laboratories. Researchers hope that improvements in culture techniques may contribute to improved RBC outcomes for blood transfusions, drug delivery and the treatment of hematological diseases. Keywords: Erythrocyte, Regeneration, HSCs, Embryonic stem cell, iPSCshttp://www.sciencedirect.com/science/article/pii/S2045976918300117
collection DOAJ
language English
format Article
sources DOAJ
author Shuming Sun
Yuanliang Peng
Jing Liu
spellingShingle Shuming Sun
Yuanliang Peng
Jing Liu
Research advances in erythrocyte regeneration sources and methods in vitro
Cell Regeneration
author_facet Shuming Sun
Yuanliang Peng
Jing Liu
author_sort Shuming Sun
title Research advances in erythrocyte regeneration sources and methods in vitro
title_short Research advances in erythrocyte regeneration sources and methods in vitro
title_full Research advances in erythrocyte regeneration sources and methods in vitro
title_fullStr Research advances in erythrocyte regeneration sources and methods in vitro
title_full_unstemmed Research advances in erythrocyte regeneration sources and methods in vitro
title_sort research advances in erythrocyte regeneration sources and methods in vitro
publisher SpringerOpen
series Cell Regeneration
issn 2045-9769
publishDate 2018-12-01
description Erythrocytes (red blood cells, RBCs) facilitate gas exchange in the lungs and transport oxygen to the tissues. The human body must maintain erythrocyte regeneration to support metabolically active cells and tissues. In many hematological diseases, erythrocyte regeneration is impaired. Researchers have studied erythrocyte regeneration for many years both in vivo and in vitro. In this review, we summarize the sources and main culture methods for generating mature and functional red blood cells in vitro. Hematopoietic stem cells (HSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are classic sources for erythrocyte regeneration. In addition, alternative sources such as immortalized adult human erythroid cell lines and transformed fibroblasts have also been generated and have produced functional red blood cells. The culture systems for erythrocytes differ among laboratories. Researchers hope that improvements in culture techniques may contribute to improved RBC outcomes for blood transfusions, drug delivery and the treatment of hematological diseases. Keywords: Erythrocyte, Regeneration, HSCs, Embryonic stem cell, iPSCs
url http://www.sciencedirect.com/science/article/pii/S2045976918300117
work_keys_str_mv AT shumingsun researchadvancesinerythrocyteregenerationsourcesandmethodsinvitro
AT yuanliangpeng researchadvancesinerythrocyteregenerationsourcesandmethodsinvitro
AT jingliu researchadvancesinerythrocyteregenerationsourcesandmethodsinvitro
_version_ 1724565827284369408

Similar Items