| Summary: | A new triterpenoid saponin, named terpengustifol A (<b>1</b>), and two new lignan glucosides, phengustifols A and B (<b>2</b> and <b>3</b>), were isolated from the flowers of <i>Elaeagnus angustifolia</i>. Their structures were determined by the extensive analysis of the spectroscopic data (including NMR and HRMS) and ECD calculations. Compound <b>1</b> possesses an unusual monoterpene (<i>Z</i>)-6-hydroxy-2,6-dimethylocta-2,7-dienoyl unit at C-21. Compounds <b>2</b> and <b>3</b> are a pair of diastereoisomers, while their aglycones are a pair of enantiomers. Compounds <b>1</b> and <b>2</b> exhibited moderate cytotoxic activities against A375 cell lines with IC<sub>50</sub> values at 12.1 and 15.6 μM, respectively. This is firstly reported the triterpenoid saponin and lignans isolated from the <i>Elaeagnus angustifolia</i> flowers.
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