Transgene IL-6 Enhances DC-Stimulated CTL Responses by Counteracting CD4+25+Foxp3+ Regulatory T Cell Suppression via IL-6-Induced Foxp3 Downregulation

Transgene IL-6 Enhances DC-Stimulated CTL Responses by Counteracting CD4+25+Foxp3+ Regulatory T Cell Suppression via IL-6-Induced Foxp3 Downregulation

Dendritic cells (DCs), the most potent antigen-presenting cells have been extensively applied in clinical trials for evaluation of antitumor immunity. However, the efficacy of DC-mediated cancer vaccines is still limited as they are unable to sufficiently break the immune tolerance. In this study, w...

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Bibliographic Details
Main Authors: Kalpana Kalyanasundaram Bhanumathy, Bei Zhang, Khawaja Ashfaque Ahmed, Mabood Qureshi, Yufeng Xie, Min Tao, Xin Tan, Jim Xiang
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:International Journal of Molecular Sciences
Subjects:
dendritic cells (DCs)
cytotoxic T lymphocytes (CTLs)
interleukin-6 (IL-6)
forkhead box P3 (Foxp3)
antitumor immunity
Online Access:http://www.mdpi.com/1422-0067/15/4/5508

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