DAPT, a γ-Secretase Inhibitor, Suppresses Tumorigenesis, and Progression of Growth Hormone-Producing Adenomas by Targeting Notch Signaling

DAPT, a γ-Secretase Inhibitor, Suppresses Tumorigenesis, and Progression of Growth Hormone-Producing Adenomas by Targeting Notch Signaling

Advances in the understanding of growth hormone-producing adenomas (GHomas) are ongoing, but current therapy is limited by moderate and variable efficacy and in need of life-long treatment. In this study, the molecular signaling pathway related to GHoma was investigated by proteomics and transcripto...

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Bibliographic Details
Main Authors: Jie Feng, Jianpeng Wang, Qian Liu, Jiye Li, Qi Zhang, Zhengping Zhuang, Xiaohui Yao, Chunhui Liu, Yangfang Li, Lei Cao, Chuzhong Li, Lei Gong, Dan Li, Yazhuo Zhang, Hua Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
pituitary adenoma
growth hormone-producing adenomas
Notch signaling
inhibitor
DAPT
invasion
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00809/full

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