The pathogenesis of HIV infection: stupid may not be so dumb after all

The pathogenesis of HIV infection: stupid may not be so dumb after all

<p>Abstract</p> <p>In the mid-1990's, researchers hypothesized, based on new viral load data, that HIV-1 causes CD4<sup>+ </sup>T-cell depletion by direct cytopathic effect. New data from non-human primate studies has raised doubts about this model of HIV-1 pathoge...

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Main Author: Smith Stephen M
Format: Article
Language:English
Published: BMC 2006-09-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/3/1/60
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spelling doaj-bf7cd9c4fa7f4fbaac9f52822bbf11762020-11-24T21:13:48ZengBMCRetrovirology1742-46902006-09-01316010.1186/1742-4690-3-60The pathogenesis of HIV infection: stupid may not be so dumb after allSmith Stephen M<p>Abstract</p> <p>In the mid-1990's, researchers hypothesized, based on new viral load data, that HIV-1 causes CD4<sup>+ </sup>T-cell depletion by direct cytopathic effect. New data from non-human primate studies has raised doubts about this model of HIV-1 pathogenesis. Despite having high levels of viremia, most SIV infections are well tolerated by their natural hosts. Two recent studies of these models provide information, which may be useful in determining how HIV-1 causes CD4<sup>+ </sup>T-cell loss. A full understanding of pathogenesis may lead to novel therapies, which preserve the immune system without blocking virus replication.</p> http://www.retrovirology.com/content/3/1/60
collection DOAJ
language English
format Article
sources DOAJ
author Smith Stephen M
spellingShingle Smith Stephen M
The pathogenesis of HIV infection: stupid may not be so dumb after all
Retrovirology
author_facet Smith Stephen M
author_sort Smith Stephen M
title The pathogenesis of HIV infection: stupid may not be so dumb after all
title_short The pathogenesis of HIV infection: stupid may not be so dumb after all
title_full The pathogenesis of HIV infection: stupid may not be so dumb after all
title_fullStr The pathogenesis of HIV infection: stupid may not be so dumb after all
title_full_unstemmed The pathogenesis of HIV infection: stupid may not be so dumb after all
title_sort pathogenesis of hiv infection: stupid may not be so dumb after all
publisher BMC
series Retrovirology
issn 1742-4690
publishDate 2006-09-01
description <p>Abstract</p> <p>In the mid-1990's, researchers hypothesized, based on new viral load data, that HIV-1 causes CD4<sup>+ </sup>T-cell depletion by direct cytopathic effect. New data from non-human primate studies has raised doubts about this model of HIV-1 pathogenesis. Despite having high levels of viremia, most SIV infections are well tolerated by their natural hosts. Two recent studies of these models provide information, which may be useful in determining how HIV-1 causes CD4<sup>+ </sup>T-cell loss. A full understanding of pathogenesis may lead to novel therapies, which preserve the immune system without blocking virus replication.</p>
url http://www.retrovirology.com/content/3/1/60
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