Liver-Derived Systemic Factors Drive β Cell Hyperplasia in Insulin-Resistant States

Liver-Derived Systemic Factors Drive β Cell Hyperplasia in Insulin-Resistant States

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Integrative organ crosstalk regulates key aspects of energy homeostasis, and its dysregulation may underlie metabolic disorders such as obesity and diabetes. To test the hypothesis that crosstalk between the liver and pancreatic islets modulates β cell growth in response to insulin resistance, we u...

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Bibliographic Details
Main Authors:	Abdelfattah El Ouaamari, Dan Kawamori, Ercument Dirice, Chong Wee Liew, Jennifer L. Shadrach, Jiang Hu, Hitoshi Katsuta, Jennifer Hollister-Lock, Wei-Jun Qian, Amy J. Wagers, Rohit N. Kulkarni
Format:	Article
Language:	English
Published:	Elsevier 2013-02-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124713000144

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