Changes in Serum Prostate-Specific Antigen Level after Prostatectomy in Patients with Benign Prostatic Hyperplasia

• Main Authors: , Seyyed Mohammad Mehdi Hosseini Moghaddam, Mohammadreza Salimi, Seyed Yousef Hosseini
• Format: Article
• Language: English
• Published: Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences 2005-04-01
• Series: Urology Journal
• Online Access: http://www.urologyjournal.org/index.php/uj/article/view/221/218

<p class="MsoNormal" style="margin: 14pt 0cm;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong><span style="mso-bidi-language: FA;">Introduction:</span></strong><span style="mso-bidi-language: FA;"> The goal of this study was to investigate the effect of transurethral resection of the prostate and open prostatectomy on the serum prostate-specific antigen (PSA) level in men with benign prostatic hyperplasia. </span></span></span></p><p class="MsoNormal" style="margin: 14pt 0cm;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong><span style="mso-bidi-language: FA;">Materials and Methods:</span></strong><span style="mso-bidi-language: FA;"> Serum prostate-specific antigen levels were determined before and 6 months after operation in 86 patients with </span>benign prostatic hyperplasia<span style="mso-bidi-language: FA;"> who had undergone transurethral resection of the prostate or open prostatectomy. We measured the prostate volume by means of transrectal ultrasonography and weighed the surgical specimen. Changes in serum PSA levels and their correlation with prostate volume and the resected prostate weight were evaluated.</span></span></span></p><p class="MsoNormal" style="margin: 14pt 0cm;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong><span style="mso-bidi-language: FA;">Results:</span></strong><span style="mso-bidi-language: FA;"> Of 86 patients, 45 underwent transurethral resection of the prostate and 41 underwent open prostatectomy. Mean PSA levels were reduced by 67.4 % (range, 0.40 ng/mL to 7.60 ng/mL) in the patients who had undergone transurethral resection of the prostate and 80.7% (range, 1.00 ng/mL to 14.50 ng/mL) in the patients with open prostatectomy. Removal of 1g of prostate tissue reduced serum PSA levels by an average of 0.15 ng/mL in those who underwent transurethral resection of the prostate and 0.10 ng/mL in those treated with open prostatectomy (<em>P</em> = .018). Forty patients (88.9%) in the group who underwent transurethral resection of the prostate and 39 (95.1%) in the open prostatectomy group exhibited a postoperative PSA level of less than 2.00 ng/mL (<em>P</em> = .20).</span></span></span></p><p class="MsoNormal" style="margin: 14pt 0cm;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong><span style="mso-bidi-language: FA;">Conclusion: </span></strong><span style="mso-bidi-language: FA;">A modified reference range seems necessary for the screening of prostate cancer via PSA level in men who have undergone prostatectomy for </span>benign prostatic hyperplasia<span style="mso-bidi-language: FA;">.<strong></strong></span></span></span></p>