Dominant-negative inhibition of canonical Notch signaling in trophoblast cells does not disrupt placenta formation

Dominant-negative inhibition of canonical Notch signaling in trophoblast cells does not disrupt placenta formation

Proper development and function of the mammalian placenta requires interactions between embryo-derived trophoblasts and uterine endothelial cells to form mosaic vessels that facilitate blood flow to a developing conceptus. Notch signaling utilizes a cell–cell contact dependent mechanism to drive cel...

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Bibliographic Details
Main Authors: Carrie J. Shawber, Dex-Ann Brown-Grant, Tracy Wu, Jan K. Kitajewski, Nataki C. Douglas
Format: Article
Language:English
Published: The Company of Biologists 2019-04-01
Series:Biology Open
Subjects:
Trophoblasts
Notch
Placenta
Cyp19-Cre
Tpbpa-Cre
Online Access:http://bio.biologists.org/content/8/4/bio037721

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