Targeting the Hindgut to Improve Health and Performance in Cattle

An adequate gastrointestinal barrier function is essential to preserve animal health and well-being. Suboptimal gut health results in the translocation of contents from the gastrointestinal lumen across the epithelium, inducing local and systemic inflammatory responses. Inflammation is characterized...

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Main Authors: M. Victoria Sanz-Fernandez, Jean-Baptiste Daniel, Dave J. Seymour, Sara K. Kvidera, Zeno Bester, John Doelman, Javier Martín-Tereso
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Animals
Subjects:
Online Access:https://www.mdpi.com/2076-2615/10/10/1817
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spelling doaj-bf444064c53a4d328e825bb1c3ef6c5e2020-11-25T02:45:14ZengMDPI AGAnimals2076-26152020-10-01101817181710.3390/ani10101817Targeting the Hindgut to Improve Health and Performance in CattleM. Victoria Sanz-Fernandez0Jean-Baptiste Daniel1Dave J. Seymour2Sara K. Kvidera3Zeno Bester4John Doelman5Javier Martín-Tereso6Trouw Nutrition Research and Development, PO Box 299, 3800 AG Amersfoort, The NetherlandsTrouw Nutrition Research and Development, PO Box 299, 3800 AG Amersfoort, The NetherlandsTrouw Nutrition Research and Development, PO Box 299, 3800 AG Amersfoort, The NetherlandsMicronutrients USA LLC, Indianapolis, IN 46241, USATrouw Nutrition Research and Development, PO Box 299, 3800 AG Amersfoort, The NetherlandsTrouw Nutrition Research and Development, PO Box 299, 3800 AG Amersfoort, The NetherlandsTrouw Nutrition Research and Development, PO Box 299, 3800 AG Amersfoort, The NetherlandsAn adequate gastrointestinal barrier function is essential to preserve animal health and well-being. Suboptimal gut health results in the translocation of contents from the gastrointestinal lumen across the epithelium, inducing local and systemic inflammatory responses. Inflammation is characterized by high energetic and nutrient requirements, which diverts resources away from production. Further, barrier function defects and inflammation have been both associated with several metabolic diseases in dairy cattle and liver abscesses in feedlots. The gastrointestinal tract is sensitive to several factors intrinsic to the productive cycles of dairy and beef cattle. Among them, high grain diets, commonly fed to support lactation and growth, are potentially detrimental for rumen health due to their increased fermentability, representing the main risk factor for the development of acidosis. Furthermore, the increase in dietary starch associated with such rations frequently results in an increase in the bypass fraction reaching distal sections of the intestine. The effects of high grain diets in the hindgut are comparable to those in the rumen and, thus, hindgut acidosis likely plays a role in grain overload syndrome. However, the relative contribution of the hindgut to this syndrome remains unknown. Nutritional strategies designed to support hindgut health might represent an opportunity to sustain health and performance in bovines.https://www.mdpi.com/2076-2615/10/10/1817gut healthhindgut acidosisinflammationlarge intestineliver abscessmetabolic disease
collection DOAJ
language English
format Article
sources DOAJ
author M. Victoria Sanz-Fernandez
Jean-Baptiste Daniel
Dave J. Seymour
Sara K. Kvidera
Zeno Bester
John Doelman
Javier Martín-Tereso
spellingShingle M. Victoria Sanz-Fernandez
Jean-Baptiste Daniel
Dave J. Seymour
Sara K. Kvidera
Zeno Bester
John Doelman
Javier Martín-Tereso
Targeting the Hindgut to Improve Health and Performance in Cattle
Animals
gut health
hindgut acidosis
inflammation
large intestine
liver abscess
metabolic disease
author_facet M. Victoria Sanz-Fernandez
Jean-Baptiste Daniel
Dave J. Seymour
Sara K. Kvidera
Zeno Bester
John Doelman
Javier Martín-Tereso
author_sort M. Victoria Sanz-Fernandez
title Targeting the Hindgut to Improve Health and Performance in Cattle
title_short Targeting the Hindgut to Improve Health and Performance in Cattle
title_full Targeting the Hindgut to Improve Health and Performance in Cattle
title_fullStr Targeting the Hindgut to Improve Health and Performance in Cattle
title_full_unstemmed Targeting the Hindgut to Improve Health and Performance in Cattle
title_sort targeting the hindgut to improve health and performance in cattle
publisher MDPI AG
series Animals
issn 2076-2615
publishDate 2020-10-01
description An adequate gastrointestinal barrier function is essential to preserve animal health and well-being. Suboptimal gut health results in the translocation of contents from the gastrointestinal lumen across the epithelium, inducing local and systemic inflammatory responses. Inflammation is characterized by high energetic and nutrient requirements, which diverts resources away from production. Further, barrier function defects and inflammation have been both associated with several metabolic diseases in dairy cattle and liver abscesses in feedlots. The gastrointestinal tract is sensitive to several factors intrinsic to the productive cycles of dairy and beef cattle. Among them, high grain diets, commonly fed to support lactation and growth, are potentially detrimental for rumen health due to their increased fermentability, representing the main risk factor for the development of acidosis. Furthermore, the increase in dietary starch associated with such rations frequently results in an increase in the bypass fraction reaching distal sections of the intestine. The effects of high grain diets in the hindgut are comparable to those in the rumen and, thus, hindgut acidosis likely plays a role in grain overload syndrome. However, the relative contribution of the hindgut to this syndrome remains unknown. Nutritional strategies designed to support hindgut health might represent an opportunity to sustain health and performance in bovines.
topic gut health
hindgut acidosis
inflammation
large intestine
liver abscess
metabolic disease
url https://www.mdpi.com/2076-2615/10/10/1817
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