Experimentally reduced insulin/IGF‐1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring

Experimentally reduced insulin/IGF‐1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring

Abstract Classical theory maintains that ageing evolves via energy trade‐offs between reproduction and survival leading to accumulation of unrepaired cellular damage with age. In contrast, the emerging new theory postulates that ageing evolves because of deleterious late‐life hyper‐function of repro...

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Bibliographic Details
Main Authors: Martin I. Lind, Sanjana Ravindran, Zuzana Sekajova, Hanne Carlsson, Andrea Hinas, Alexei A. Maklakov
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Evolution Letters
Subjects:
Ageing
antagonistic pleiotropy
functional trade‐offs
hyperfunction
IIS signaling
parental effects
Online Access:https://doi.org/10.1002/evl3.108

Internet

https://doi.org/10.1002/evl3.108

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