INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

The Integrator complex (INT) is responsible for the 3′-end processing of several classes of non-coding RNAs. Here the authors show that the INTS10-INTS13-INTS14 complex forms a distinct submodule of INT and suggest it facilitates RNA substrate targeting.

Bibliographic Details
Main Authors:	Kevin Sabath, Melanie L. Stäubli, Sabrina Marti, Alexander Leitner, Murielle Moes, Stefanie Jonas
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17232-2

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spelling	doaj-bf3f2057cddb4eac81b86a74bf8c43512021-07-11T11:44:41ZengNature Publishing GroupNature Communications2041-17232020-07-0111111610.1038/s41467-020-17232-2INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage moduleKevin Sabath0Melanie L. Stäubli1Sabrina Marti2Alexander Leitner3Murielle Moes4Stefanie Jonas5Institute of Molecular Biology and Biophysics, ETH ZurichInstitute of Molecular Biology and Biophysics, ETH ZurichInstitute of Molecular Biology and Biophysics, ETH ZurichInstitute of Molecular Systems Biology, ETH ZurichInstitute of Molecular Biology and Biophysics, ETH ZurichInstitute of Molecular Biology and Biophysics, ETH ZurichThe Integrator complex (INT) is responsible for the 3′-end processing of several classes of non-coding RNAs. Here the authors show that the INTS10-INTS13-INTS14 complex forms a distinct submodule of INT and suggest it facilitates RNA substrate targeting.https://doi.org/10.1038/s41467-020-17232-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kevin Sabath Melanie L. Stäubli Sabrina Marti Alexander Leitner Murielle Moes Stefanie Jonas
spellingShingle	Kevin Sabath Melanie L. Stäubli Sabrina Marti Alexander Leitner Murielle Moes Stefanie Jonas INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module Nature Communications
author_facet	Kevin Sabath Melanie L. Stäubli Sabrina Marti Alexander Leitner Murielle Moes Stefanie Jonas
author_sort	Kevin Sabath
title	INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module
title_short	INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module
title_full	INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module
title_fullStr	INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module
title_full_unstemmed	INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module
title_sort	ints10–ints13–ints14 form a functional module of integrator that binds nucleic acids and the cleavage module
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	The Integrator complex (INT) is responsible for the 3′-end processing of several classes of non-coding RNAs. Here the authors show that the INTS10-INTS13-INTS14 complex forms a distinct submodule of INT and suggest it facilitates RNA substrate targeting.
url	https://doi.org/10.1038/s41467-020-17232-2
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INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

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