Development of Radiolabeled Membrane Type-1 Matrix Metalloproteinase Activatable Cell Penetrating Peptide Imaging Probes

Development of Radiolabeled Membrane Type-1 Matrix Metalloproteinase Activatable Cell Penetrating Peptide Imaging Probes

Membrane type-1 matrix metalloproteinase (MT1-MMP or MMP-14) plays an important role in adverse cardiac remodelling. Here, we aimed to develop radiolabeled activatable cell penetrating peptides (ACPP) sensitive to MT1-MMP for the detection of elevated MT1-MMP levels in adverse cardiac remodelling. T...

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Bibliographic Details
Main Authors: Sander M. J. van Duijnhoven, Marc S. Robillard, Klaas Nicolay, Holger Grüll
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Molecules
Subjects:
molecular imaging
activatable cell penetrating peptide
matrix metalloproteinase-14
membrane type-1 matrix metalloproteinase
radiolabeling
myocardial infarction
peptide chemistry
Online Access:http://www.mdpi.com/1420-3049/20/7/12076

Internet

http://www.mdpi.com/1420-3049/20/7/12076

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