Hsp74, a Potential Bladder Cancer Marker, Has Direct Interaction with Keratin 1

Hsp74, a Potential Bladder Cancer Marker, Has Direct Interaction with Keratin 1

Early diagnosis and prognosis monitoring are very important for the survival of patients with bladder cancer. To identify candidate biomarkers of bladder cancer, we used a combination of techniques including 2-DE, co-IP, western blot, LC-MS/MS, and immunohistochemistry. Hsp74 was identified with hig...

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Main Authors: Ling Chen, YaRong Wang, Le Zhao, Wei Chen, Chunhui Dong, Xinhan Zhao, Xu Li
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2014/492849
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spelling doaj-bf2fbe6cdbc44f1b992feba43ed30d3a2020-11-24T23:14:49ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/492849492849Hsp74, a Potential Bladder Cancer Marker, Has Direct Interaction with Keratin 1Ling Chen0YaRong Wang1Le Zhao2Wei Chen3Chunhui Dong4Xinhan Zhao5Xu Li6Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, ChinaTranslational Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaTranslational Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaTranslational Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaEarly diagnosis and prognosis monitoring are very important for the survival of patients with bladder cancer. To identify candidate biomarkers of bladder cancer, we used a combination of techniques including 2-DE, co-IP, western blot, LC-MS/MS, and immunohistochemistry. Hsp74 was identified with high expression in bladder cancer. The cellular location of expression products of gene Hsp74 showed that they were distributed into cytoplasm and keratin 1 was found to be associated with Hsp74. The results provide a new idea to understand the molecular basis of bladder cancer progression and pinpoint new potential molecular target for early diagnosis and therapeutic monitoring of bladder cancer.http://dx.doi.org/10.1155/2014/492849
collection DOAJ
language English
format Article
sources DOAJ
author Ling Chen
YaRong Wang
Le Zhao
Wei Chen
Chunhui Dong
Xinhan Zhao
Xu Li
spellingShingle Ling Chen
YaRong Wang
Le Zhao
Wei Chen
Chunhui Dong
Xinhan Zhao
Xu Li
Hsp74, a Potential Bladder Cancer Marker, Has Direct Interaction with Keratin 1
Journal of Immunology Research
author_facet Ling Chen
YaRong Wang
Le Zhao
Wei Chen
Chunhui Dong
Xinhan Zhao
Xu Li
author_sort Ling Chen
title Hsp74, a Potential Bladder Cancer Marker, Has Direct Interaction with Keratin 1
title_short Hsp74, a Potential Bladder Cancer Marker, Has Direct Interaction with Keratin 1
title_full Hsp74, a Potential Bladder Cancer Marker, Has Direct Interaction with Keratin 1
title_fullStr Hsp74, a Potential Bladder Cancer Marker, Has Direct Interaction with Keratin 1
title_full_unstemmed Hsp74, a Potential Bladder Cancer Marker, Has Direct Interaction with Keratin 1
title_sort hsp74, a potential bladder cancer marker, has direct interaction with keratin 1
publisher Hindawi Limited
series Journal of Immunology Research
issn 2314-8861
2314-7156
publishDate 2014-01-01
description Early diagnosis and prognosis monitoring are very important for the survival of patients with bladder cancer. To identify candidate biomarkers of bladder cancer, we used a combination of techniques including 2-DE, co-IP, western blot, LC-MS/MS, and immunohistochemistry. Hsp74 was identified with high expression in bladder cancer. The cellular location of expression products of gene Hsp74 showed that they were distributed into cytoplasm and keratin 1 was found to be associated with Hsp74. The results provide a new idea to understand the molecular basis of bladder cancer progression and pinpoint new potential molecular target for early diagnosis and therapeutic monitoring of bladder cancer.
url http://dx.doi.org/10.1155/2014/492849
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AT yarongwang hsp74apotentialbladdercancermarkerhasdirectinteractionwithkeratin1
AT lezhao hsp74apotentialbladdercancermarkerhasdirectinteractionwithkeratin1
AT weichen hsp74apotentialbladdercancermarkerhasdirectinteractionwithkeratin1
AT chunhuidong hsp74apotentialbladdercancermarkerhasdirectinteractionwithkeratin1
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