Low-dose radiation activates Nrf1/2 through reactive species and the Ca2+/ERK1/2 signaling pathway in human skin fibroblast cells

Low-dose radiation activates Nrf1/2 through reactive species and the Ca2+/ERK1/2 signaling pathway in human skin fibroblast cells

In the current study, we explored the effect of LDR on theactivation of Nrfs transcription factor involved in cellular redoxevents. Experiments were carried out utilizing 0.05 and 0.5 GyX-ray irradiated normal human skin fibroblast HS27 cells. Theresults showed LDR induced Nrf1 and Nrf2 activation a...

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Bibliographic Details
Main Authors: Eun Kyeong Lee, Jin-Ah Kim, Seong Joon Park, Jeung Ki Kim, Kyu Heo, Kwang Mo Yang, Tae Gen Son
Format: Article
Language:English
Published: Korean Society for Biochemistry and Molecular Biology 2013-05-01
Series:BMB Reports
Subjects:
Ca2+
ERK1/2
Nrf1/2
Reactive species
X-ray
Online Access:http://bmbreports.org/jbmb/pdf.php?data=MTMwOTI3MTFAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni01JTVEMTMwNTI5MjIzMF8lMjgyNTgtMjYzJTI5Qk1CXzEyLTE5OS5wZGY=

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