Overexpression of the human <it>MNB/DYRK1A </it>gene induces formation of multinucleate cells through overduplication of the centrosome

Overexpression of the human <it>MNB/DYRK1A </it>gene induces formation of multinucleate cells through overduplication of the centrosome

<p>Abstract</p> <p>Background</p> <p>Previously we cloned the human <it>MNB/DYRK1A </it>gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on se...

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Bibliographic Details
Main Authors: Hiraoka Yasushi, Haraguchi Tokuko, Hori Takamitsu, Funakoshi Eishi, Kudoh Jun, Shimizu Nobuyoshi, Ito Fumiaki
Format: Article
Language:English
Published: BMC 2003-09-01
Series:BMC Cell Biology
Subjects:
Down syndrome critical region
Dual-specificity protein kinase
Centrosome
Cell cycle
MNB/DYRK1A.
Online Access:http://www.biomedcentral.com/1471-2121/4/12

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