Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms.

Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms.

Inactivation of the tumor suppressor gene p53 is commonly observed in human prostate cancer and is associated with therapeutic resistance. We have previously demonstrated that green tea polyphenols (GTP) induce apoptosis in prostate cancer cells irrespective of p53 status. However, the molecular mec...

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Bibliographic Details
Main Authors: Karishma Gupta, Vijay S Thakur, Natarajan Bhaskaran, Akbar Nawab, Melissa A Babcook, Mark W Jackson, Sanjay Gupta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3527608?pdf=render

Internet

http://europepmc.org/articles/PMC3527608?pdf=render

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