A cross-species assessment of behavioral flexibility in compulsive disorders

A cross-species assessment of behavioral flexibility in compulsive disorders

Nabil Benzina et al. use a reversal learning task to examine behavioral flexibility in human and mouse models of obsessive compulsive disorder (OCD). They report that only subsets of human patients or OCD-like mice show deficits in behavioral flexibility, highlighting the diverse presentation of cog...

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Main Authors: Nabil Benzina, Karim N’Diaye, Antoine Pelissolo, Luc Mallet, Eric Burguière
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01611-y
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spelling doaj-bf203c13df764bb8980102de4e6c90be2021-01-24T12:24:46ZengNature Publishing GroupCommunications Biology2399-36422021-01-014111210.1038/s42003-020-01611-yA cross-species assessment of behavioral flexibility in compulsive disordersNabil Benzina0Karim N’Diaye1Antoine Pelissolo2Luc Mallet3Eric Burguière4Institut du Cerveau, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, 47 bd de l’HôpitalInstitut du Cerveau, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, 47 bd de l’HôpitalAssistance Publique-Hôpitaux de Paris, DMU IMPACT, Département Médical-Universitaire de Psychiatrie et d’Addictologie, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Université Paris-Est CréteilInstitut du Cerveau, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, 47 bd de l’HôpitalInstitut du Cerveau, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, 47 bd de l’HôpitalNabil Benzina et al. use a reversal learning task to examine behavioral flexibility in human and mouse models of obsessive compulsive disorder (OCD). They report that only subsets of human patients or OCD-like mice show deficits in behavioral flexibility, highlighting the diverse presentation of cognitive deficits in compulsive disorders.https://doi.org/10.1038/s42003-020-01611-y
collection DOAJ
language English
format Article
sources DOAJ
author Nabil Benzina
Karim N’Diaye
Antoine Pelissolo
Luc Mallet
Eric Burguière
spellingShingle Nabil Benzina
Karim N’Diaye
Antoine Pelissolo
Luc Mallet
Eric Burguière
A cross-species assessment of behavioral flexibility in compulsive disorders
Communications Biology
author_facet Nabil Benzina
Karim N’Diaye
Antoine Pelissolo
Luc Mallet
Eric Burguière
author_sort Nabil Benzina
title A cross-species assessment of behavioral flexibility in compulsive disorders
title_short A cross-species assessment of behavioral flexibility in compulsive disorders
title_full A cross-species assessment of behavioral flexibility in compulsive disorders
title_fullStr A cross-species assessment of behavioral flexibility in compulsive disorders
title_full_unstemmed A cross-species assessment of behavioral flexibility in compulsive disorders
title_sort cross-species assessment of behavioral flexibility in compulsive disorders
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-01-01
description Nabil Benzina et al. use a reversal learning task to examine behavioral flexibility in human and mouse models of obsessive compulsive disorder (OCD). They report that only subsets of human patients or OCD-like mice show deficits in behavioral flexibility, highlighting the diverse presentation of cognitive deficits in compulsive disorders.
url https://doi.org/10.1038/s42003-020-01611-y
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