Gastroparesis in a Patient with Gastric AL Amyloidosis

• Main Authors: Matthew Hoscheit, Afrin Kamal, Michael Cline
• Format: Article
• Language: English
• Published: Karger Publishers 2018-06-01
• Series: Case Reports in Gastroenterology
• Subjects: AL amyloidosis; Gastroparesis; Gastrointestinal amyloidosis
• Online Access: https://www.karger.com/Article/FullText/489297

Systemic amyloidosis is a group of complex disorders characterized by the extracellular deposition of nonbranching fibrils in various tissues, ultimately leading to a variety of clinical presentations including isolated or multiorgan dysfunction. Amyloid involvement of the gastrointestinal tract is common depending on the subtype of this disease; light chain primary amyloidosis (AL) and secondary amyloidosis (AA) affect the gastrointestinal tract in unique ways due to differing pathophysiology. A case is reported of gastroparesis associated with AL amyloidosis diagnosed by esophagogastroduodenoscopy and study of gastric emptying, then subsequently confirmed by Congo red staining performed on endoscopic biopsies.