Investigation for biomechanical and biochemical characteristic changes of kidney, liver and duodenum tissues according to inflation time of REBOA

• Main Authors: Dongman Ryu, Up Huh, Seungik Baek, Il Jae Wang, Chi-Seung Lee
• Format: Article
• Language: English
• Published: Elsevier 2021-07-01
• Series: Materials & Design
• Subjects: Resuscitative Endovascular Balloon Occlusion of Aorta; Blood Test; Inflation Time; Mechanical Property; Compression Test; Uniaxial Tensile Test
• Online Access: http://www.sciencedirect.com/science/article/pii/S0264127521002707

In the study on emergency treatment of massive hemorrhage, it is important to investigate the duration of inflation time in resuscitative endovascular balloon occlusion of aorta (REBOA). REBOA temporarily controls bleeding and maintains the blood pressure while causing side effects to the other organs. To elucidate the side effects of REBOA on the main organs and establish their clinical criteria, both mechanical behavior and clinical examination of each organ tissue must be characterized based on the operation time. Particularly, two rate-dependent mechanical tests (tensile and compression tests) and tissue blood tests (blood urea nitrogen, creatinine, aspartate aminotransferase, and lactate tests) of the kidney, liver, and duodenum tissues were examined according to the inflation time of REBOA. Finally, it was demonstrated that the characteristic of the soft tissue by the loading rate was maintained even in the ischemic tissue. In addition, based on the presented results, it was confirmed that the inflation time of REBOA have an effect on the variation in properties of several organ tissues.