Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?

Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?

The use of natural products has definitely been the most successful strategy in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natura...

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Main Authors: Marilia Valli, Marcos Pivatto, Amanda Danuello, Ian Castro-Gamboa, Dulce Helena Siqueira Silva, Alberto José Cavalheiro, Ângela Regina Araújo, Maysa Furlan, Márcia Nasser Lopes, Vanderlan da Silva Bolzani
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2012-01-01
Series:Química Nova
Subjects:
natural products
medicinal chemistry
tropical biodiversity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100036&lng=en&tlng=en
id doaj-befe47c8ecc247268567b4d016089f08
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spelling doaj-befe47c8ecc247268567b4d016089f082020-11-24T23:50:15ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642012-01-0135112278228710.1590/S0100-40422012001100036S0100-40422012001100036Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?Marilia Valli0Marcos Pivatto1Amanda Danuello2Ian Castro-Gamboa3Dulce Helena Siqueira Silva4Alberto José Cavalheiro5Ângela Regina Araújo6Maysa Furlan7Márcia Nasser Lopes8Vanderlan da Silva Bolzani9Universidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual PaulistaThe use of natural products has definitely been the most successful strategy in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. This paper seeks to show the great value of secondary metabolites and emphasize the rich chemical diversity of Brazilian biodiversity. This natural chemical library remains understudied, but can be a useful source of new secondary metabolites with potential application as templates for drug discovery.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100036&lng=en&tlng=ennatural productsmedicinal chemistrytropical biodiversity
collection DOAJ
language English
format Article
sources DOAJ
author Marilia Valli
Marcos Pivatto
Amanda Danuello
Ian Castro-Gamboa
Dulce Helena Siqueira Silva
Alberto José Cavalheiro
Ângela Regina Araújo
Maysa Furlan
Márcia Nasser Lopes
Vanderlan da Silva Bolzani
spellingShingle Marilia Valli
Marcos Pivatto
Amanda Danuello
Ian Castro-Gamboa
Dulce Helena Siqueira Silva
Alberto José Cavalheiro
Ângela Regina Araújo
Maysa Furlan
Márcia Nasser Lopes
Vanderlan da Silva Bolzani
Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?
Química Nova
natural products
medicinal chemistry
tropical biodiversity
author_facet Marilia Valli
Marcos Pivatto
Amanda Danuello
Ian Castro-Gamboa
Dulce Helena Siqueira Silva
Alberto José Cavalheiro
Ângela Regina Araújo
Maysa Furlan
Márcia Nasser Lopes
Vanderlan da Silva Bolzani
author_sort Marilia Valli
title Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?
title_short Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?
title_full Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?
title_fullStr Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?
title_full_unstemmed Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?
title_sort tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?
publisher Sociedade Brasileira de Química
series Química Nova
issn 1678-7064
publishDate 2012-01-01
description The use of natural products has definitely been the most successful strategy in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. This paper seeks to show the great value of secondary metabolites and emphasize the rich chemical diversity of Brazilian biodiversity. This natural chemical library remains understudied, but can be a useful source of new secondary metabolites with potential application as templates for drug discovery.
topic natural products
medicinal chemistry
tropical biodiversity
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100036&lng=en&tlng=en
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AT amandadanuello tropicalbiodiversityhasitbeenapotentialsourceofsecondarymetabolitesusefulformedicinalchemistry
AT iancastrogamboa tropicalbiodiversityhasitbeenapotentialsourceofsecondarymetabolitesusefulformedicinalchemistry
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AT angelareginaaraujo tropicalbiodiversityhasitbeenapotentialsourceofsecondarymetabolitesusefulformedicinalchemistry
AT maysafurlan tropicalbiodiversityhasitbeenapotentialsourceofsecondarymetabolitesusefulformedicinalchemistry
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