Membrane Binding and Insertion of a pHLIP Peptide Studied by All-Atom Molecular Dynamics Simulations

Membrane Binding and Insertion of a pHLIP Peptide Studied by All-Atom Molecular Dynamics Simulations

Recent experiments in function mechanism study reported that a pH low-insertion peptide (pHLIP) can insert into a zwitterionic palmitoyloleoylphosphatidylcholine (POPC) lipid bilayer at acidic pH while binding to the bilayer surface at basic pH. However, the atomic details of the pH-dependent intera...

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Bibliographic Details
Main Authors: Guanghong Wei, Yuguang Mu, Yun Zhang, Yin Luo, Zhenyu Qian, Yonghua Deng
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:International Journal of Molecular Sciences
Subjects:
pH low-insertion peptide (pHLIP)
zwitterionic POPC
pH-triggered bilayer insertion
membrane binding
all-atom molecular dynamics simulations
Online Access:http://www.mdpi.com/1422-0067/14/7/14532

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