Novel Bis- and Mono-Pyrrolo[2,3-<i>d</i>]pyrimidine and Purine Derivatives: Synthesis, Computational Analysis and Antiproliferative Evaluation

Novel Bis- and Mono-Pyrrolo[2,3-<i>d</i>]pyrimidine and Purine Derivatives: Synthesis, Computational Analysis and Antiproliferative Evaluation

Novel symmetrical bis-pyrrolo[2,3-<i>d</i>]pyrimidines and bis-purines and their monomers were synthesized and evaluated for their antiproliferative activity in human lung adenocarcinoma (A549), cervical carcinoma (HeLa), ductal pancreatic adenocarcinoma (CFPAC-1) and metastatic colorect...

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Bibliographic Details
Main Authors: Andrea Bistrović Popov, Robert Vianelo, Petra Grbčić, Mirela Sedić, Sandra Kraljević Pavelić, Krešimir Pavelić, Silvana Raić-Malić
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
pyrrolo[2,3-<i>d</i>]pyrimidines
purine
DFT calculations
ultrasound
antiproliferative activity
pancreatic adenocarcinoma
Online Access:https://www.mdpi.com/1420-3049/26/11/3334

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https://www.mdpi.com/1420-3049/26/11/3334

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