The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells

The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells

Statins, including simvastatin (SMV), are commonly used for the control of hyperlipidaemia and have also proven therapeutic and preventative effects in cardiovascular diseases. Besides that, there is an emerging interest in their use as antineoplastic drugs as demonstrated by different studies showi...

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Bibliographic Details
Main Authors: Zuhier A. Awan, Usama A. Fahmy, Shaimaa M. Badr-Eldin, Tarek S. Ibrahim, Hani Z. Asfour, Mohammed W. Al-Rabia, Anas Alfarsi, Nabil A. Alhakamy, Wesam H. Abdulaal, Hadeel Al Sadoun, Nawal Helmi, Ahmad O. Noor, Filippo Caraci, Diena M. Almasri, Giuseppe Caruso
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceutics
Subjects:
simvastatin
cell cycle
apoptosis
emulsomes
cytotoxicity
breast cancer
Online Access:https://www.mdpi.com/1999-4923/12/7/597

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