Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens.

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens.

Two-component, self-assembling nanoparticles represent a versatile platform for multivalent presentation of viral antigens. Computational design of protein nanoparticles with differing sizes and geometries enables combination with antigens of choice to test novel multimerization concepts in immuniza...

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Bibliographic Details
Main Authors: Aleksandar Antanasijevic, George Ueda, Philip J M Brouwer, Jeffrey Copps, Deli Huang, Joel D Allen, Christopher A Cottrell, Anila Yasmeen, Leigh M Sewall, Ilja Bontjer, Thomas J Ketas, Hannah L Turner, Zachary T Berndsen, David C Montefiori, Per Johan Klasse, Max Crispin, David Nemazee, John P Moore, Rogier W Sanders, Neil P King, David Baker, Andrew B Ward
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008665

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