Dissociation of bone resorption and bone formation in adult mice with a non-functional V-ATPase in osteoclasts leads to increased bone strength.

Dissociation of bone resorption and bone formation in adult mice with a non-functional V-ATPase in osteoclasts leads to increased bone strength.

Osteopetrosis caused by defective acid secretion by the osteoclast, is characterized by defective bone resorption, increased osteoclast numbers, while bone formation is normal or increased. In contrast the bones are of poor quality, despite this uncoupling of formation from resorption.To shed light...

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Bibliographic Details
Main Authors: Kim Henriksen, Carmen Flores, Jesper S Thomsen, Anne-Marie Brüel, Christian S Thudium, Anita V Neutzsky-Wulff, Geerling E J Langenbach, Natalie Sims, Maria Askmyr, Thomas J Martin, Vincent Everts, Morten A Karsdal, Johan Richter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3210177?pdf=render

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