Comprehensive genome-wide analysis of routine non-invasive test data allows cancer prediction: A single-center retrospective analysis of over 85,000 pregnancies

Comprehensive genome-wide analysis of routine non-invasive test data allows cancer prediction: A single-center retrospective analysis of over 85,000 pregnancies

Background: Implausible false positive results in non-invasive prenatal testing (NIPT) have been occasionally associated with the detection of occult maternal malignancies. Hence, there is a need for approaches allowing accurate prediction of whether the NIPT result is pointing to an underlying mali...

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Main Authors: Liesbeth Lenaerts, PhD, Nathalie Brison, PhD, Charlotte Maggen, MD, Leen Vancoillie, PhD, Huiwen Che, MsC, Peter Vandenberghe, MD, PhD, Daan Dierickx, MD, PhD, Lucienne Michaux, MD, Phd, Barbara Dewaele, PhD, Patrick Neven, MD, PhD, Giuseppe Floris, MD, PhD, Thomas Tousseyn, MD, PhD, Lore Lannoo, MD, Tatjana Jatsenko, PhD, Isabelle Vanden Bempt, PhD, Kristel Van Calsteren, MD, PhD, Vincent Vandecaveye, MD, PhD, Luc Dehaspe, PhD, Koenraad Devriendt, MD, PhD, Eric Legius, MD, PhD, Kris Van Den Bogaert, PhD, Joris Robert Vermeesch, PhD, Frédéric Amant, MD, PhD
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:EClinicalMedicine
Subjects:
Non-invasive prenatal testing
Cancer detection
Clinical follow-up
Online Access:http://www.sciencedirect.com/science/article/pii/S258953702100136X

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