Memory immune response: a major challenge in vaccination

A crucial challenge for vaccine development is to design vaccines that induce a long-lasting protective immune response, i.e., immune memory. The persistence of antigen-specific antibody titers over a protective threshold, and the ability to exibit a ‘recall response’ to a subsequent encounter with...

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Main Authors: Prisco Antonella, De Berardinis Piergiuseppe
Format: Article
Language:English
Published: De Gruyter 2012-10-01
Series:Biomolecular Concepts
Subjects:
Online Access:https://doi.org/10.1515/bmc-2012-0010
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spelling doaj-bee1b7408efc421884465d59d0bd46602021-09-05T20:42:33ZengDe GruyterBiomolecular Concepts1868-50211868-503X2012-10-013547948610.1515/bmc-2012-0010Memory immune response: a major challenge in vaccinationPrisco Antonella0De Berardinis Piergiuseppe1Institute of Genetics and Biophysics, CNR, via P. Castellino 111, 80131 Naples, ItalyInstitute of Protein Biochemistry, CNR, via P. Castellino 111, 80131 Naples, ItalyA crucial challenge for vaccine development is to design vaccines that induce a long-lasting protective immune response, i.e., immune memory. The persistence of antigen-specific antibody titers over a protective threshold, and the ability to exibit a ‘recall response’ to a subsequent encounter with an antigen have long been the only measurable correlates of vaccine take and immune memory development, suffering from the disadvantage of relying on long-term monitoring of the immune response. In the last few years, advances in the technologies for the identification and characterization of the cell subsets and molecular pathways involved in the immune response to vaccination have allowed innovative approaches to the identification of early correlates of immune memory. In this review, we discuss recent data and hypotheses on early correlates of the development of immune memory, with special emphasis on the gene expression signatures that underlie the self-renewal ability of some lymphocyte subsets, and their similarities with gene expression signatures in stem cells.https://doi.org/10.1515/bmc-2012-0010humoral responseimmune memoryself-renewalsystems biologyvaccination
collection DOAJ
language English
format Article
sources DOAJ
author Prisco Antonella
De Berardinis Piergiuseppe
spellingShingle Prisco Antonella
De Berardinis Piergiuseppe
Memory immune response: a major challenge in vaccination
Biomolecular Concepts
humoral response
immune memory
self-renewal
systems biology
vaccination
author_facet Prisco Antonella
De Berardinis Piergiuseppe
author_sort Prisco Antonella
title Memory immune response: a major challenge in vaccination
title_short Memory immune response: a major challenge in vaccination
title_full Memory immune response: a major challenge in vaccination
title_fullStr Memory immune response: a major challenge in vaccination
title_full_unstemmed Memory immune response: a major challenge in vaccination
title_sort memory immune response: a major challenge in vaccination
publisher De Gruyter
series Biomolecular Concepts
issn 1868-5021
1868-503X
publishDate 2012-10-01
description A crucial challenge for vaccine development is to design vaccines that induce a long-lasting protective immune response, i.e., immune memory. The persistence of antigen-specific antibody titers over a protective threshold, and the ability to exibit a ‘recall response’ to a subsequent encounter with an antigen have long been the only measurable correlates of vaccine take and immune memory development, suffering from the disadvantage of relying on long-term monitoring of the immune response. In the last few years, advances in the technologies for the identification and characterization of the cell subsets and molecular pathways involved in the immune response to vaccination have allowed innovative approaches to the identification of early correlates of immune memory. In this review, we discuss recent data and hypotheses on early correlates of the development of immune memory, with special emphasis on the gene expression signatures that underlie the self-renewal ability of some lymphocyte subsets, and their similarities with gene expression signatures in stem cells.
topic humoral response
immune memory
self-renewal
systems biology
vaccination
url https://doi.org/10.1515/bmc-2012-0010
work_keys_str_mv AT priscoantonella memoryimmuneresponseamajorchallengeinvaccination
AT deberardinispiergiuseppe memoryimmuneresponseamajorchallengeinvaccination
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