Normal Ribosomal Biogenesis but Shortened Protein Synthetic Response to Acute Eccentric Resistance Exercise in Old Skeletal Muscle

Normal Ribosomal Biogenesis but Shortened Protein Synthetic Response to Acute Eccentric Resistance Exercise in Old Skeletal Muscle

Anabolic resistance to feeding in aged muscle is well-characterized; however, whether old skeletal muscle is intrinsically resistant to acute mechanical loading is less clear. The aim of this study was to determine the impact of aging on muscle protein synthesis (MPS), ribosome biogenesis, and prote...

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Bibliographic Details
Main Authors: Daniel W. D. West, George R. Marcotte, Courtney M. Chason, Natalie Juo, Leslie M. Baehr, Sue C. Bodine, Keith Baar
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Physiology
Subjects:
ribosome biogenesis
ER stress
ubiquitin proteasome
IRS-1 signaling
anabolic resistance
sarcopenia
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01915/full

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