Intracellular insulin in human tumors: examples and implications
<p>Abstract</p> <p>Insulin is one of the major metabolic hormones regulating glucose homeostasis in the organism and a key growth factor for normal and neoplastic cells. Work conducted primarily over the past 3 decades has unravelled the presence of insulin in human breast cancer t...
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| Format: | Article |
| Language: | English |
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BMC
2011-04-01
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| Series: | Diabetology & Metabolic Syndrome |
| Online Access: | http://www.dmsjournal.com/content/3/1/5 |
| Summary: | <p>Abstract</p> <p>Insulin is one of the major metabolic hormones regulating glucose homeostasis in the organism and a key growth factor for normal and neoplastic cells. Work conducted primarily over the past 3 decades has unravelled the presence of insulin in human breast cancer tissues and, more recently, in human non-small cell lung carcinomas (NSCLC). These findings have suggested that intracellular insulin is involved in the development of these highly prevalent human tumors. A potential mechanism for such involvement is insulin's binding and inactivation of the retinoblastoma tumor suppressor protein (RB) which in turn is likely controlled by insulin-degrading enzyme (IDE). This model and its supporting data are collectively covered in this survey in order to provide further insight into insulin-driven oncogenesis and its reversal through future anticancer therapeutics.</p> |
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| ISSN: | 1758-5996 |