The Plasmodium export element revisited.

The Plasmodium export element revisited.

We performed a bioinformatical analysis of protein export elements (PEXEL) in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions. We demonstrate that the family...

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Main Authors: Jan Alexander Hiss, Jude Marek Przyborski, Florian Schwarte, Klaus Lingelbach, Gisbert Schneider
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-02-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18253504/?tool=EBI
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spelling doaj-bed9213ee1f545e7a89c49ffd6b667812021-03-03T19:55:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-02-0132e156010.1371/journal.pone.0001560The Plasmodium export element revisited.Jan Alexander HissJude Marek PrzyborskiFlorian SchwarteKlaus LingelbachGisbert SchneiderWe performed a bioinformatical analysis of protein export elements (PEXEL) in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions. We demonstrate that the family members can be clustered based on the flanking regions only and display characteristic hydrophobicity patterns. This raises the possibility that the flanking regions may contain additional information for a family-specific role of PEXEL. We further show that signal peptide cleavage results in a positional alignment of PEXEL from both proteins with, and without, a signal peptide.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18253504/?tool=EBI
collection DOAJ
language English
format Article
sources DOAJ
author Jan Alexander Hiss
Jude Marek Przyborski
Florian Schwarte
Klaus Lingelbach
Gisbert Schneider
spellingShingle Jan Alexander Hiss
Jude Marek Przyborski
Florian Schwarte
Klaus Lingelbach
Gisbert Schneider
The Plasmodium export element revisited.
PLoS ONE
author_facet Jan Alexander Hiss
Jude Marek Przyborski
Florian Schwarte
Klaus Lingelbach
Gisbert Schneider
author_sort Jan Alexander Hiss
title The Plasmodium export element revisited.
title_short The Plasmodium export element revisited.
title_full The Plasmodium export element revisited.
title_fullStr The Plasmodium export element revisited.
title_full_unstemmed The Plasmodium export element revisited.
title_sort plasmodium export element revisited.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2008-02-01
description We performed a bioinformatical analysis of protein export elements (PEXEL) in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions. We demonstrate that the family members can be clustered based on the flanking regions only and display characteristic hydrophobicity patterns. This raises the possibility that the flanking regions may contain additional information for a family-specific role of PEXEL. We further show that signal peptide cleavage results in a positional alignment of PEXEL from both proteins with, and without, a signal peptide.
url https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18253504/?tool=EBI
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