The protective effects of mangiferin on metabolic and organs functions in the adolescent rat model of alcohol abuse

• Main Authors: Ce Chu, Mengran Li, Jianheng Li, Chengyan Zhou
• Format: Article
• Language: English
• Published: Elsevier 2018-07-01
• Series: Journal of Functional Foods
• Subjects: Mangiferin; Alcohol abuse; Adolescent; Glial fibrillary acidic protein; Insulin receptor substrate-2; Growth differentiation factor-9
• Online Access: http://www.sciencedirect.com/science/article/pii/S1756464618301956

This study was carried out to investigate the beneficial effects and potential mechanism of mangiferin (MG) against the disorders of metabolic and organs functions induced by alcohol abuse (40% alcohol, 10 mL/kg day−1 BW, ig) in adolescent rats. MG administration (100 mg/kg·day−1 BW, ig) can effectively prevent the above disorders. The mechanisms of potential effect of MG were related to scavenged free radicals, increased the levels of serum calcium, estradiol, testosterone and bone density, and up-regulated brain GFAP, testes IRS-2 and ovaries GDF-9 expression levels. In addition, lipid accumulation and blood glucose level were effectively regulated by MG, which are also important for adolescent metabolic and organs functions. These systems and balances in vivo were not isolated from each other, but interrelated and influenced each other. These results suggested that MG can be a novel phytochemicals for preventing the disorders of metabolic and organs functions induced by alcohol abuse.