Short-Term Culture with the Caspase Inhibitor z-VAD.fmk Reduces Beta Cell Apoptosis in Transplanted Islets and Improves the Metabolic Outcome of the Graft

Short-Term Culture with the Caspase Inhibitor z-VAD.fmk Reduces Beta Cell Apoptosis in Transplanted Islets and Improves the Metabolic Outcome of the Graft

In the initial days after transplantation islets are particularly vulnerable and show increased apoptosis and necrosis. We have studied the effects of caspase inhibition on this early beta cell death in syngeneically transplanted islets. Streptozotocin-diabetic C57BL/6 mice were transplanted with 15...

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Bibliographic Details
Main Authors: Marta Montolio, Noèlia Téllez, Montserrat Biarnés, Joan Soler, Eduard Montanya
Format: Article
Language:English
Published: SAGE Publishing 2005-01-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/000000005783983269

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