TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

TERRA RNA has previously been linked to Alternative lengthening of telomeres (ALT). Here the authors developed a tool to rapidly inhibit TERRA transcription from different chromosome ends in an ALT cell line to show that TERRA transcription actively promotes break induced replication (BIR) and desta...

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Bibliographic Details
Main Authors: Bruno Silva, Rajika Arora, Silvia Bione, Claus M. Azzalin
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24097-6

Internet

https://doi.org/10.1038/s41467-021-24097-6

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