Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice

Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice

<p>Abstract</p> <p>Background</p> <p>Sirtuins are important regulators of glucose and fat metabolism, and sirtuin activation has been proposed as a therapeutic target for insulin resistance and diabetes. We have shown leucine to increase mitochondrial biogenesis and fat...

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Bibliographic Details
Main Authors: Bruckbauer Antje, Zemel Michael B, Thorpe Teresa, Akula Murthy R, Stuckey Alan C, Osborne Dustin, Martin Emily B, Kennel Stephen, Wall Jonathan S
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Nutrition & Metabolism
Subjects:
Diabetes
HMB
Inflammatory stress
Insulin-resistance
Leucine
Obesity
Resveratrol
Sirt1
Sirt3
Synergy
Online Access:http://www.nutritionandmetabolism.com/content/9/1/77

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