CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism

CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism

B-cell acute lymphocytic leukemia (B-ALL), a common blood cancer in children, leads to high mortality. Cyclin-dependent kinase 9 inhibitor (CDK9i) effectively attenuates acute myeloid leukemia and chronic lymphoblastic leukemia by inducing apoptosis and inhibiting cell proliferation. However, the ef...

Full description

Bibliographic Details
Main Authors: Wen-Li Huang, Tuersunayi Abudureheman, Jing Xia, Lei Chu, Hang Zhou, Wei-Wei Zheng, Neng Zhou, Rong-Yi Shi, Ming-Hao Li, Jian-Min Zhu, Kai Qing, Chao Ji, Kai-Wei Liang, Sa Guo, Gang Yin, Cai-Wen Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CDK9 inhibitors
cell apoptosis
glycolysis
c-Myc
B-cell acute lymphocytic leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.641271/full

Similar Items

Similar Items