Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature

Calcium channel antagonists (CCAs) are commonly involved in drug overdoses. Standard approaches to the management of CCA overdoses, including fluid resuscitation, gut decontamination, administration of calcium, glucagon, and atropine, as well as supportive care, are often ineffective. We report on t...

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Main Authors:	Shiwan K. Shah, Sanjeev Kumar Goswami, Rajesh V. Babu, Gulshan Sharma, Alexander G. Duarte
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Case Reports in Critical Care
Online Access:	http://dx.doi.org/10.1155/2012/927040

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spelling	doaj-bea8ff6baca24897a1268597995238b12020-11-24T23:06:08ZengHindawi LimitedCase Reports in Critical Care2090-64202090-64392012-01-01201210.1155/2012/927040927040Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the LiteratureShiwan K. Shah0Sanjeev Kumar Goswami1Rajesh V. Babu2Gulshan Sharma3Alexander G. Duarte4Department of Internal Medicine and Pediatrics, University of Texas Medical Branch, 301 University Boulevard, Route 0354, Gaveston, TX 77555, USADepartment of Pulmonary, Allergy, and Critical Care, University of Texas Medical Branch, Gaveston, TX 77555, USADepartment of Pulmonary, Allergy, and Critical Care, University of Texas Medical Branch, Gaveston, TX 77555, USADepartment of Pulmonary, Allergy, and Critical Care, University of Texas Medical Branch, Gaveston, TX 77555, USADepartment of Pulmonary, Allergy, and Critical Care, University of Texas Medical Branch, Gaveston, TX 77555, USACalcium channel antagonists (CCAs) are commonly involved in drug overdoses. Standard approaches to the management of CCA overdoses, including fluid resuscitation, gut decontamination, administration of calcium, glucagon, and atropine, as well as supportive care, are often ineffective. We report on two patients who improved after addition of hyperinsulinemia-euglycemia (HIE) therapy. We conclude with a literature review on hyperinsulinemia-euglycemia therapy with an exploration of the physiology behind its potential use.http://dx.doi.org/10.1155/2012/927040
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shiwan K. Shah Sanjeev Kumar Goswami Rajesh V. Babu Gulshan Sharma Alexander G. Duarte
spellingShingle	Shiwan K. Shah Sanjeev Kumar Goswami Rajesh V. Babu Gulshan Sharma Alexander G. Duarte Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature Case Reports in Critical Care
author_facet	Shiwan K. Shah Sanjeev Kumar Goswami Rajesh V. Babu Gulshan Sharma Alexander G. Duarte
author_sort	Shiwan K. Shah
title	Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature
title_short	Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature
title_full	Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature
title_fullStr	Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature
title_full_unstemmed	Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature
title_sort	management of calcium channel antagonist overdose with hyperinsulinemia-euglycemia therapy: case series and review of the literature
publisher	Hindawi Limited
series	Case Reports in Critical Care
issn	2090-6420 2090-6439
publishDate	2012-01-01
description	Calcium channel antagonists (CCAs) are commonly involved in drug overdoses. Standard approaches to the management of CCA overdoses, including fluid resuscitation, gut decontamination, administration of calcium, glucagon, and atropine, as well as supportive care, are often ineffective. We report on two patients who improved after addition of hyperinsulinemia-euglycemia (HIE) therapy. We conclude with a literature review on hyperinsulinemia-euglycemia therapy with an exploration of the physiology behind its potential use.
url	http://dx.doi.org/10.1155/2012/927040
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Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature

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