Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature

Calcium channel antagonists (CCAs) are commonly involved in drug overdoses. Standard approaches to the management of CCA overdoses, including fluid resuscitation, gut decontamination, administration of calcium, glucagon, and atropine, as well as supportive care, are often ineffective. We report on t...

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Bibliographic Details
Main Authors: Shiwan K. Shah, Sanjeev Kumar Goswami, Rajesh V. Babu, Gulshan Sharma, Alexander G. Duarte
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Case Reports in Critical Care
Online Access:http://dx.doi.org/10.1155/2012/927040
Description
Summary:Calcium channel antagonists (CCAs) are commonly involved in drug overdoses. Standard approaches to the management of CCA overdoses, including fluid resuscitation, gut decontamination, administration of calcium, glucagon, and atropine, as well as supportive care, are often ineffective. We report on two patients who improved after addition of hyperinsulinemia-euglycemia (HIE) therapy. We conclude with a literature review on hyperinsulinemia-euglycemia therapy with an exploration of the physiology behind its potential use.
ISSN:2090-6420
2090-6439