A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B

A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B

Upon autophagy induction, LC3 is cleaved by the protease ATG4 and conjugated to the autophagosomal membrane; however, its removal is mediated by the same protease. Here the authors show that ULK1-mediated phosphorylation and PP2A-mediated dephosphorylation of ATG4 regulates its cellular activity to...

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Main Authors: N. Pengo, A. Agrotis, K. Prak, J. Jones, R. Ketteler
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00303-2
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spelling doaj-be9d8c9445e94d1a89cc7a77d68e8daf2021-01-31T12:26:06ZengNature Publishing GroupNature Communications2041-17232017-08-018111010.1038/s41467-017-00303-2A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4BN. Pengo0A. Agrotis1K. Prak2J. Jones3R. Ketteler4MRC Laboratory for Molecular Cell Biology, University College LondonMRC Laboratory for Molecular Cell Biology, University College LondonMRC Laboratory for Molecular Cell Biology, University College LondonMRC Laboratory for Molecular Cell Biology, University College LondonMRC Laboratory for Molecular Cell Biology, University College LondonUpon autophagy induction, LC3 is cleaved by the protease ATG4 and conjugated to the autophagosomal membrane; however, its removal is mediated by the same protease. Here the authors show that ULK1-mediated phosphorylation and PP2A-mediated dephosphorylation of ATG4 regulates its cellular activity to control LC3 processing.https://doi.org/10.1038/s41467-017-00303-2
collection DOAJ
language English
format Article
sources DOAJ
author N. Pengo
A. Agrotis
K. Prak
J. Jones
R. Ketteler
spellingShingle N. Pengo
A. Agrotis
K. Prak
J. Jones
R. Ketteler
A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
Nature Communications
author_facet N. Pengo
A. Agrotis
K. Prak
J. Jones
R. Ketteler
author_sort N. Pengo
title A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
title_short A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
title_full A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
title_fullStr A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
title_full_unstemmed A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B
title_sort reversible phospho-switch mediated by ulk1 regulates the activity of autophagy protease atg4b
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-08-01
description Upon autophagy induction, LC3 is cleaved by the protease ATG4 and conjugated to the autophagosomal membrane; however, its removal is mediated by the same protease. Here the authors show that ULK1-mediated phosphorylation and PP2A-mediated dephosphorylation of ATG4 regulates its cellular activity to control LC3 processing.
url https://doi.org/10.1038/s41467-017-00303-2
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