Synthesis of Novel Halogenated Heterocycles Based on <i>o</i>-Phenylenediamine and Their Interactions with the Catalytic Subunit of Protein Kinase CK2

Synthesis of Novel Halogenated Heterocycles Based on <i>o</i>-Phenylenediamine and Their Interactions with the Catalytic Subunit of Protein Kinase CK2

Protein kinase CK2 is a highly pleiotropic protein kinase capable of phosphorylating hundreds of protein substrates. It is involved in numerous cellular functions, including cell viability, apoptosis, cell proliferation and survival, angiogenesis, or ER-stress response. As CK2 activity is found pert...

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Bibliographic Details
Main Authors: Maria Winiewska-Szajewska, Agnieszka Monika Maciejewska, Elżbieta Speina, Jarosław Poznański, Daniel Paprocki
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
kinase CK2
differential scanning fluorimetry
molecular modeling
halogenated heterocycles
hydrophobic contribution
ligand binding
Online Access:https://www.mdpi.com/1420-3049/26/11/3163

Internet

https://www.mdpi.com/1420-3049/26/11/3163

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