Effect of mid-frequency pulse therapy combined with external fixation on bone metabolism, inflammatory response and oxidative stress in patients with osteoporotic distal radial fractures

• Main Authors: Bao-Ning Luo, Guo-Xin Wang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-09-01
• Series: Journal of Hainan Medical University
• Subjects: Osteoporotic distal radial fracture; Mid-frequency pulse therapy; Bone metabolism; Inflammatory response; Oxidative stress
• Online Access: http://www.hnykdxxb.com/PDF/201717/18.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the effect of mid-frequency pulse therapy combined with external fixation on bone metabolism, inflammatory response and oxidative stress in patients with osteoporotic distal radial fractures. Methods: A total of 72 patients with osteoporotic distal radial fractures who were treated in the hospital between September 2015 and January 2017 were collected and divided into control group (n=36) and observation group (n=36) according to the random number table method. Control group received routine external fixation, and observation group received mid-frequency pulse therapy combined with external fixation. The differences in serum levels of bone metabolism indexes, inflammatory factors and oxidative stress indexes were compared between two groups of patients before and after treatment. Results: Before treatment, differences in serum levels of bone metabolism indexes, inflammatory factors and oxidative stress indexes were not statistically significant between the two groups. After 1 month of treatment, serum BGP, TAC and SOD levels of both groups of patients were higher than those before treatment while β-CTX, AKP, TRAP, CRP, IL-1β, IL-6 and MDA levels were lower than those before treatment, and serum BGP, TAC and SOD levels of observation group were higher than those of control group while β-CTX, AKP, TRAP, CRP, IL-1β, IL-6 and MDA levels were lower than those of control group. Conclusion: Mid-frequency pulse therapy combined with external fixation can promote fracture healing and reduce postoperative inflammatory response and oxidative stress response in patients with osteoporotic distal radial fracture.