Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage

Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage

Abstract.: Vasospasm after subarachnoid hemorrhage (SAH) is a serious complication and we have been investigating the relationship between vasoconstrictors and vasospasm after SAH. The present study was designed to investigate the vasocontractile responses to reactive oxygen species in isolated rat...

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Main Authors: Tsuyoshi Nishihashi, Cristina C. Trandafir, Aimin Wang, Xu Ji, Yoshiharu Shimizu, Kazuyoshi Kurahashi
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319345207
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spelling doaj-be91abace2e14d41b1e2bf63604899f52020-11-25T02:06:26ZengElsevierJournal of Pharmacological Sciences1347-86132006-01-011003234236Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid HemorrhageTsuyoshi Nishihashi0Cristina C. Trandafir1Aimin Wang2Xu Ji3Yoshiharu Shimizu4Kazuyoshi Kurahashi5Pharmacology Division, RI Center, Kyoto University, Kyoto 606-8501, JapanPharmacology Division, RI Center, Kyoto University, Kyoto 606-8501, JapanPharmacology Division, RI Center, Kyoto University, Kyoto 606-8501, JapanPharmacology Division, RI Center, Kyoto University, Kyoto 606-8501, JapanDepartment of Community Health, School of Medicine, Tokai University, Kanagawa 228-8555, JapanPharmacology Division, RI Center, Kyoto University, Kyoto 606-8501, Japan; Corresponding author. kkura@barium.rirc.kyoto-u.ac.jpAbstract.: Vasospasm after subarachnoid hemorrhage (SAH) is a serious complication and we have been investigating the relationship between vasoconstrictors and vasospasm after SAH. The present study was designed to investigate the vasocontractile responses to reactive oxygen species in isolated rat basilar arteries from the control and experimental SAH rats. Contractile responses to hydroxyl radicals in basilar arteries from SAH rats were 3 – 6-fold higher than those in control rats. The present results clearly indicate that hypersensitivity to hydroxyl radicals may contribute to the vasospasm after SAH. Keywords:: subarachnoid hemorrhage, hydroxyl radical, rat basilar arteryhttp://www.sciencedirect.com/science/article/pii/S1347861319345207
collection DOAJ
language English
format Article
sources DOAJ
author Tsuyoshi Nishihashi
Cristina C. Trandafir
Aimin Wang
Xu Ji
Yoshiharu Shimizu
Kazuyoshi Kurahashi
spellingShingle Tsuyoshi Nishihashi
Cristina C. Trandafir
Aimin Wang
Xu Ji
Yoshiharu Shimizu
Kazuyoshi Kurahashi
Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage
Journal of Pharmacological Sciences
author_facet Tsuyoshi Nishihashi
Cristina C. Trandafir
Aimin Wang
Xu Ji
Yoshiharu Shimizu
Kazuyoshi Kurahashi
author_sort Tsuyoshi Nishihashi
title Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage
title_short Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage
title_full Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage
title_fullStr Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage
title_full_unstemmed Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage
title_sort hypersensitivity to hydroxyl radicals in rat basilar artery after subarachnoid hemorrhage
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2006-01-01
description Abstract.: Vasospasm after subarachnoid hemorrhage (SAH) is a serious complication and we have been investigating the relationship between vasoconstrictors and vasospasm after SAH. The present study was designed to investigate the vasocontractile responses to reactive oxygen species in isolated rat basilar arteries from the control and experimental SAH rats. Contractile responses to hydroxyl radicals in basilar arteries from SAH rats were 3 – 6-fold higher than those in control rats. The present results clearly indicate that hypersensitivity to hydroxyl radicals may contribute to the vasospasm after SAH. Keywords:: subarachnoid hemorrhage, hydroxyl radical, rat basilar artery
url http://www.sciencedirect.com/science/article/pii/S1347861319345207
work_keys_str_mv AT tsuyoshinishihashi hypersensitivitytohydroxylradicalsinratbasilararteryaftersubarachnoidhemorrhage
AT cristinactrandafir hypersensitivitytohydroxylradicalsinratbasilararteryaftersubarachnoidhemorrhage
AT aiminwang hypersensitivitytohydroxylradicalsinratbasilararteryaftersubarachnoidhemorrhage
AT xuji hypersensitivitytohydroxylradicalsinratbasilararteryaftersubarachnoidhemorrhage
AT yoshiharushimizu hypersensitivitytohydroxylradicalsinratbasilararteryaftersubarachnoidhemorrhage
AT kazuyoshikurahashi hypersensitivitytohydroxylradicalsinratbasilararteryaftersubarachnoidhemorrhage
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