SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

T-acute lymphoblastic leukemia is an aggressive cancer. Here the authors provide insights into the functional role of SHQ1, an H/ACA snoRNP assembly factor involved in snRNA pseudouridylation, in T-lymphoblastic leukemia cell survival through regulating the maturation of MYC mRNA.

Bibliographic Details
Main Authors: Hexiu Su, Juncheng Hu, Liang Huang, Yang Yang, Morgan Thenoz, Anna Kuchmiy, Yufeng Hu, Peng Li, Hui Feng, Yu Zhou, Tom Taghon, Pieter Van Vlierberghe, Guoliang Qing, Zhichao Chen, Hudan Liu
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06523-4

Internet

https://doi.org/10.1038/s41467-018-06523-4

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