SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival
T-acute lymphoblastic leukemia is an aggressive cancer. Here the authors provide insights into the functional role of SHQ1, an H/ACA snoRNP assembly factor involved in snRNA pseudouridylation, in T-lymphoblastic leukemia cell survival through regulating the maturation of MYC mRNA.
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06523-4 |
| id |
doaj-be84c2167969446dbc4de6875a3ebd48 |
|---|---|
| record_format |
Article |
| spelling |
doaj-be84c2167969446dbc4de6875a3ebd482021-05-11T10:32:57ZengNature Publishing GroupNature Communications2041-17232018-10-019111510.1038/s41467-018-06523-4SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survivalHexiu Su0Juncheng Hu1Liang Huang2Yang Yang3Morgan Thenoz4Anna Kuchmiy5Yufeng Hu6Peng Li7Hui Feng8Yu Zhou9Tom Taghon10Pieter Van Vlierberghe11Guoliang Qing12Zhichao Chen13Hudan Liu14Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyMedical Research Institute, Wuhan UniversityDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCollege of Life Sciences, Wuhan UniversityDepartment of Biomolecular Medicine, Ghent UniversityDepartment of Clinical Chemistry, Microbiology and Immunology, Ghent UniversityZhongnan Hospital of Wuhan UniversitySouth China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesDepartment of Pharmacology and Department of Medicine, Cancer Research Center, Section of Hematology and Medical Oncology, Boston University School of MedicineCollege of Life Sciences, Wuhan UniversityDepartment of Clinical Chemistry, Microbiology and Immunology, Ghent UniversityDepartment of Biomolecular Medicine, Ghent UniversityMedical Research Institute, Wuhan UniversityInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyMedical Research Institute, Wuhan UniversityT-acute lymphoblastic leukemia is an aggressive cancer. Here the authors provide insights into the functional role of SHQ1, an H/ACA snoRNP assembly factor involved in snRNA pseudouridylation, in T-lymphoblastic leukemia cell survival through regulating the maturation of MYC mRNA.https://doi.org/10.1038/s41467-018-06523-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hexiu Su Juncheng Hu Liang Huang Yang Yang Morgan Thenoz Anna Kuchmiy Yufeng Hu Peng Li Hui Feng Yu Zhou Tom Taghon Pieter Van Vlierberghe Guoliang Qing Zhichao Chen Hudan Liu |
| spellingShingle |
Hexiu Su Juncheng Hu Liang Huang Yang Yang Morgan Thenoz Anna Kuchmiy Yufeng Hu Peng Li Hui Feng Yu Zhou Tom Taghon Pieter Van Vlierberghe Guoliang Qing Zhichao Chen Hudan Liu SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival Nature Communications |
| author_facet |
Hexiu Su Juncheng Hu Liang Huang Yang Yang Morgan Thenoz Anna Kuchmiy Yufeng Hu Peng Li Hui Feng Yu Zhou Tom Taghon Pieter Van Vlierberghe Guoliang Qing Zhichao Chen Hudan Liu |
| author_sort |
Hexiu Su |
| title |
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival |
| title_short |
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival |
| title_full |
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival |
| title_fullStr |
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival |
| title_full_unstemmed |
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival |
| title_sort |
shq1 regulation of rna splicing is required for t-lymphoblastic leukemia cell survival |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-10-01 |
| description |
T-acute lymphoblastic leukemia is an aggressive cancer. Here the authors provide insights into the functional role of SHQ1, an H/ACA snoRNP assembly factor involved in snRNA pseudouridylation, in T-lymphoblastic leukemia cell survival through regulating the maturation of MYC mRNA. |
| url |
https://doi.org/10.1038/s41467-018-06523-4 |
| work_keys_str_mv |
AT hexiusu shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT junchenghu shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT lianghuang shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT yangyang shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT morganthenoz shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT annakuchmiy shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT yufenghu shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT pengli shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT huifeng shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT yuzhou shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT tomtaghon shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT pietervanvlierberghe shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT guoliangqing shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT zhichaochen shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival AT hudanliu shq1regulationofrnasplicingisrequiredfortlymphoblasticleukemiacellsurvival |
| _version_ |
1721447980883509248 |