MKRN2 inhibits migration and invasion of non-small-cell lung cancer by negatively regulating the PI3K/Akt pathway

MKRN2 inhibits migration and invasion of non-small-cell lung cancer by negatively regulating the PI3K/Akt pathway

Abstract Background Makorin RING zinc finger-2 (MKRN2) belongs to the makorin RING zinc finger family and is a novel ubiquitin E3 ligase targeting the p65 subunit of NF-κB to negatively regulate inflammatory responses; however, the relationship between MKRN2 and tumorigenesis remains unclear. In thi...

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Bibliographic Details
Main Authors: Jun Jiang, Yitong Xu, Hongjiu Ren, Muli Wudu, Qiongzi Wang, Xin Song, Hongbo Su, Xizi Jiang, Lihong Jiang, Xueshan Qiu
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Non-small-cell lung cancer
MKRN2
Cell migration
Cell invasion
PI3K/Akt pathway
Ubiquitination
Online Access:http://link.springer.com/article/10.1186/s13046-018-0855-7

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http://link.springer.com/article/10.1186/s13046-018-0855-7

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