Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

Primate lentiviruses encode four "accessory proteins" including Vif, Vpu, Nef, and Vpr/Vpx. Vif and Vpu counteract the antiviral effects of cellular restrictions to early and late steps in the viral replication cycle. We present evidence that the Vpx proteins of HIV-2/SIV(SM) promote virus...

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Bibliographic Details
Main Authors: Natalia Sharova, Yuanfei Wu, Xiaonan Zhu, Ruzena Stranska, Rajnish Kaushik, Mark Sharkey, Mario Stevenson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2323106?pdf=render

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http://europepmc.org/articles/PMC2323106?pdf=render

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